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Clip of Misfiring Mitochondria (shortened version)

Mitochondria live inside your cells and regulate energy, metabolism, and cellular signaling to drive your body’s physiology, endurance, and resilience. The function, dynamics, and efficiency of mitochondria correlate with either health and well-being or poor health and sickness.

Normal aging, diet, exercise, exposure to stressors, and other variables have been proven to impact mitochondrial function (energetics) and dynamics (shape and size).¹⁻³ The maintenance of mitochondrial function and dynamics are essential to health.⁴ Individuals who have a disease, are sick, or are in poor health will have poorly functioning mitochondria and compromised dynamics. Individuals who eat properly, have good sleep hygiene, train, or exercise demonstrate improved mitochondrial function and dynamics.

The mescreen™ is a mitochondrial efficiency screen that provides an energetic profile of your cells and ultimately of you. Establishing a baseline mescreen™ score and tracking it over time provides you with a tool to assess your mitochondrial function. mescreen™ is also part of an ongoing research project that will allow you to compare your mescreen™ score in the future against other populations that are sick, healthy, elite performance, and other to gauge where your cellular health and mitochondrial function are at.

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#175 | Misfiring Mitochondria | Hemal Patel PhD

Everyone has heard the analogies about VO2max being the size of your engine, or an empty fuel tank being like depleted muscle glycogen. But no one talks about: the fuel injection system (or carburetor for us old guys).

Mitochondria…yours, mine, everyone’s mitochondria via the electron transport chain are nature’s original fuel injector..working to combine *just the right amount* of fuel and oxygen for whatever power output you need in that moment. Too little fuel? You get poor performance, sputtering, loss of power. Too much fuel flooding the system? You get wasted gas, incomplete combustion, carbon buildup, and harmful exhaust—maybe even a fire under the hood….ever hear about ROS and free radicals?

But here’s the thing: this system can fail in dozens of different ways. Maybe you’re missing key nutrients that act like spark plugs. Maybe your mitochondrial membranes are damaged, causing fuel to leak and oxidize before it can be used. Maybe you’ve got too few but efficient mitochondria or maybe you’ve got lots of old, sloppy ones spewing out reactive oxygen species like an engine with bad rings dumping oil smoke.

The problem is, most people are flying blind. They’re trying every supplement, every training protocol, every recovery hack that worked for someone else—without understanding *how their own mitochondria are actually failing*. It’s like throwing parts at a car without diagnosing what’s actually broken.

Today, we’re going to change that. Today I’m talking with dr Hemal Patel of the university of California San Diego and the creator of the me screen mitochondrial assessment developed for NASA to learn how to diagnose your cellular fuel injection system, identify *your* specific bottlenecks, and address the root cause. Because at the end of the day? It’s not about training harder. It’s about training smarter—all right, let’s talk to Hemal Patel

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