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Speaker: Joe Lavelle

Clip of Misfiring Mitochondria (shortened version)

Mitochondria live inside your cells and regulate energy, metabolism, and cellular signaling to drive your body’s physiology, endurance, and resilience. The function, dynamics, and efficiency of mitochondria correlate with either health and well-being or poor health and sickness.

Normal aging, diet, exercise, exposure to stressors, and other variables have been proven to impact mitochondrial function (energetics) and dynamics (shape and size).¹⁻³ The maintenance of mitochondrial function and dynamics are essential to health.⁴ Individuals who have a disease, are sick, or are in poor health will have poorly functioning mitochondria and compromised dynamics. Individuals who eat properly, have good sleep hygiene, train, or exercise demonstrate improved mitochondrial function and dynamics.

The mescreen™ is a mitochondrial efficiency screen that provides an energetic profile of your cells and ultimately of you. Establishing a baseline mescreen™ score and tracking it over time provides you with a tool to assess your mitochondrial function. mescreen™ is also part of an ongoing research project that will allow you to compare your mescreen™ score in the future against other populations that are sick, healthy, elite performance, and other to gauge where your cellular health and mitochondrial function are at.

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#175 | Misfiring Mitochondria | Hemal Patel PhD

Everyone has heard the analogies about VO2max being the size of your engine, or an empty fuel tank being like depleted muscle glycogen. But no one talks about: the fuel injection system (or carburetor for us old guys).

Mitochondria…yours, mine, everyone’s mitochondria via the electron transport chain are nature’s original fuel injector..working to combine *just the right amount* of fuel and oxygen for whatever power output you need in that moment. Too little fuel? You get poor performance, sputtering, loss of power. Too much fuel flooding the system? You get wasted gas, incomplete combustion, carbon buildup, and harmful exhaust—maybe even a fire under the hood….ever hear about ROS and free radicals?

But here’s the thing: this system can fail in dozens of different ways. Maybe you’re missing key nutrients that act like spark plugs. Maybe your mitochondrial membranes are damaged, causing fuel to leak and oxidize before it can be used. Maybe you’ve got too few but efficient mitochondria or maybe you’ve got lots of old, sloppy ones spewing out reactive oxygen species like an engine with bad rings dumping oil smoke.

The problem is, most people are flying blind. They’re trying every supplement, every training protocol, every recovery hack that worked for someone else—without understanding *how their own mitochondria are actually failing*. It’s like throwing parts at a car without diagnosing what’s actually broken.

Today, we’re going to change that. Today I’m talking with dr Hemal Patel of the university of California San Diego and the creator of the me screen mitochondrial assessment developed for NASA to learn how to diagnose your cellular fuel injection system, identify *your* specific bottlenecks, and address the root cause. Because at the end of the day? It’s not about training harder. It’s about training smarter—all right, let’s talk to Hemal Patel

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#174 | Dodging Dementia in the Older Athlete | Amanda Wiggins, PhD

Whether you’re a competitive age-group athlete, a fitness enthusiast turning “masters”, or simply someone who wants to stay mentally sharp as you age—this episode is for you. We’re going to bridge the gap between athletic longevity and brain longevity.

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#173 | Optimizing Body Composition | Michael Ormsbee, PhD

Body composition and athletic performance are inseparably intertwined topics. Body composition is good for health, self-esteem and performance. Athletic performance is good for health (body is built to move), longevity (3 factors) and body composition (burning calories vs. consuming calories vs. desired body comp change) vs. stimulus for change (calorie deficit for fat loss until the body adapts AND resistance training for muscle / strength and/or endurance training for mitochondria biogenesis)

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#172 | Levers of (Food) Satiety | Dr Ted Naiman

Professional Supplements for Wise Athletes (click to see the always discount) Dr Ted Naiman Bio: Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading major medical center in Seattle. Dr. Naiman holds an undergraduate degree in mechanical engineering, which influences his analytical approach to medicine. He…

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#171 | Managing Glucose for Athletes | Hunter Allen, Peaks Coaching Group

Managing blood glucose is not only important for health and longevity, it impacts athletic performance in real time. Wearing a CGM provides access to the raw data needed to manage glucose via diet, feed schedule, activity. For athletic performance, keeping blood glucose in the high performance zone means no bonking or premature fatigue.

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#170 | Sweat Equity: Fitness is a Good Start | Frank Schwartz, Nant’an of F3

F3 Nation is a free, peer-led movement designed to help men get fit, build bonds of friendship, and learn how to join forces to serve the community.

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#169 | A Big Life | Adrian Kelly

Am I living my best life or am I merely passing time…just sustaining my least tolerable life….neither failing nor succeeding in building a life of meaning. I want to know how can I live a big life instead of merely a long one?
To answer this question, Today I am joined by Adrian Kelly, the author of The Success Complex in which he explains the nuanced nature of success in life…the path to having a meaningful life in which we can look back with satisfaction in a life well lived, the feeling of having had a full life rather than one that seemed too short, with too many regrets for things not done ….Adrian points out that true fulfillment arises not merely from achievements or the ownership of things or even the level of cumulative pleasure vs. suffering over time….. but from aligning one’s actions with a deeper sense of purpose. Kelly presents a framework to help individuals navigate their unique paths to meaningful success. And it all starts today and is built one day at a time.
Carpe Diem.

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#168 | Mito Boosters: Methylene Blue & Urolithin A | Richard LaFountain, Phd & Brandon Fell, MS

Mitochondrial health is all the rage right now, and frankly I’m a big believer. I’m doing everything I can to improve my mitochondrial health…including taking two of darlings of the internet: methylene blue and urolithin A. As you’ll know from past episodes I’ve had great success with methylene blue despite how crazy taking a synthetic dye into my body regularly sounds to me. More recently, and against all the advice I’ve received from guests on the show, I started taking urolithin A as an experiment…just to see if I could get any benefit…and 2 months in I cannot say it’s been a success. Dang.
The good news is I have the Healthspan guys, Rich and Brandon back for part 2, to explain the Healthspan thinking on these two chemicals they provide to their clients. They walk through lall the whys and hows of the safety and benefits to be had. This was a great chat

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#167 | Navigating Bloodwork | Richard LaFountain, PhD & Brandon Fell, MS of Healthspan

Using my personal blood test data, we get into how healthspan helps their clients to assess health status and plot an improvement trajectory that leads with lifestyle improvements and augmented with on & off-label pharmaceuticals to help us become functionally younger, and possibly dramatically extend our healthspan and time in life as an strong athlete

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