Professional Supplements for Wise Athletes (click to see the huge “always on” discount)

Affordable (best pricing by far) Blood Testing at GoodLabs (use code WISE for 20% discount)

Jose Areta, PhD

• Dr. José Areta is an Associate Professor in Exercise Metabolism and Nutrition at the School of Sport and Exercise Sciences, Liverpool John Moores University (UK). Originally from Argentina and trained first as a biologist (with a minor in zoology), he completed his PhD in exercise physiology and nutrition at RMIT University in Melbourne, then spent roughly three years as a postdoctoral researcher at the Norwegian School of Sport Sciences before moving to Liverpool. His research centers on training–nutrition interactions in humans — how manipulating carbohydrate, protein, fat, and overall energy availability shapes adaptation to training and physical performance. In recent years his work has focused on the endocrine, metabolic, and physiological effects of energy deficiency, including the first dynamic proteomic profiling of how human skeletal muscle responds to a short-term energy deficit combined with exercise. He is also a practicing athlete, coach, and practitioner, and has roughly 60 peer-reviewed publications.

• Jose Areta, PhD profile

• Most of us treat an energy deficit as a problem to be corrected — a state where you’ve fallen below a known requirement, risking lost muscle and blunted performance. Areta’s reframe: think of it as energy stress. Like exercise stress, it’s a signal the body is built to adapt to, and — at least as a working hypothesis — one you may get better at handling with repeated, progressive exposure. We (probably) evolved under intermittent scarcity, and a body that responded to hunger by becoming weak and slow wouldn’t have survived to find its next meal. The practical hook for the older athlete: if you’re always in a calorie surplus to recover and build, you’re adding fat alongside muscle. Energy stress, used deliberately, becomes the tool for managing body (low) fatness without sacrificing the performance and muscle you’ve worked for.

Key learnings

1. You can get stronger in a deficit without getting bigger. Energy deficit plus resistance training yields the same strength gains as energy-balanced training — but without the same hypertrophy. The gains come from neuromuscular adaptation, not added mass. (Function over form.)
2. Protein is the lever that makes a deficit safe. Requirements rise to roughly 2.2 g/kg/day to preserve lean mass during a deficit. The threshold that matters: deficits beyond about 500 kcal/day impair muscle-building even with training; below that, recomposition (muscle gain + fat loss) stays achievable.
3. Fat is the fuel; contractile muscle is largely spared. In Areta’s short-term deficit study, energy came predominantly from fat oxidation, and most of the apparent “lean loss” was water — the contractile machinery was preserved.
4. The deficit upregulates mitochondrial machinery. Deficit-plus-exercise increased mitochondrial protein synthesis and quality-control proteins — the stress acted as an adaptive signal, not just depletion. Meanwhile the collagen “scaffolding” proteins that rise with aging were reduced — though whether that’s net-beneficial isn’t yet settled.
5. The body has no fixed metabolic rate. It adjusts expenditure and efficiency to energy availability (the Hadza/Pontzer finding: lots of activity, not many extra calories burned). Caveat: this is bounded, not unlimited, and the interpretation is debated.
6. Performance testing at the bottom of a deficit will mislead you. Low muscle glycogen impairs high-intensity output, so refeed before anything that matters — don’t judge your true capacity, or the strategy, by how you feel mid-deficit.
7. The load-bearing question — “functionally superior muscle.” The most exciting idea (that energy stress yields muscle that’s stronger per unit mass) is also where human outcome data is thinnest. Treat it as a promising hypothesis, not an established finding. 

Discussion outline

1. The reframe — why “energy stress” beats “energy deficit,” and the exercise-stress / progressive-overload analogy
2. The evolutionary lens — why locomotion and physical capacity are protected under scarcity
3. Macronutrients first — carbohydrate, fat, and protein around training, and what too much / too little looks like
4. Strength without size — neuromuscular adaptation vs. hypertrophy in a deficit
5. Protein as the safety lever — the ~2.2 g/kg/day target and the ~500 kcal/day deficit threshold
6. Inside the muscle — the proteomics study: mitochondrial upregulation, ECM/collagen reduction, preserved contractile protein
7. Is there a basal metabolic rate? — adaptive efficiency, the Hadza data, and what it means for “calories in/out”
8. The glycogen catch — why deficit impairs high-intensity performance and when to refeed
9. The REDs debate — Areta’s critique of single-cause framing, and the allostatic-load alternative
10. The open protocol question — cycle energy stress vs. find a sustained minimum floor; is calories or protein the bigger driver?
11. Practical takeaways for the older athlete — using deficit to manage body fat while protecting muscle and performance

Studies & further reading

• Areta, J.L. (2023). Physical performance during energy deficiency in humans: an evolutionary perspective.Comparative Biochemistry and Physiology Part A, 284, 111473. doi:10.1016/j.cbpa.2023.111473 — the core “energy stress” / evolutionary argument. Open-access PDF: researchonline.ljmu.ac.uk/id/eprint/23006/
• Areta et al. (2021). Low energy availability: history, definition and evidence of its endocrine, metabolic and physiological effects in prospective studies in females and males. (Review of the LEA evidence base.)
• The proteomics intervention study — short-term pronounced energy deficit + aerobic training and its effect on skeletal-muscle proteomic, metabolic, and endocrine adaptation (the mitochondrial-up / ECM-down finding). Discussed in depth on Sigma Nutrition Radio #594 (Feb 2026): sigmanutrition.com/episode594/
• Murphy, C. & Koehler, K. (2022). Energy deficiency impairs resistance training gains in lean mass but not strength: a meta-analysis and meta-regression. Scand J Med Sci Sports, 32:125–137 — the basis for “strength preserved, size not.”
• Areta et al. Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit. Am J Physiol Endocrinol Metab — the MPS-rescue finding.
• Melin et al. (2023). Direct and indirect impact of low energy availability on sports performance.
• Areta lab, world-tour female cyclist case study (Tour de France Femmes, 2023) — a real-world example of extreme energy expenditure and the limits of performance as a marker of fueling.
• Guest links: LJMU research profile and ResearchGate (full publication list); Areta on Sigma Nutrition Radio #508 and #594, and That Triathlon Show #378, for prior long-form discussions.

Summary

• Most of us treat an energy deficit as a problem to be corrected — a state where you’ve fallen below a known requirement, risking lost muscle and blunted performance. Areta’s reframe: think of it as energy stress. Like exercise stress, it’s a signal the body is built to adapt to, and — at least as a working hypothesis — one you may get better at handling with repeated, progressive exposure. We evolved under intermittent scarcity, and a body that responded to hunger by becoming weak and slow wouldn’t have survived to find its next meal. The practical hook for the older athlete: if you’re always in a calorie surplus to recover and build, you’re adding fat alongside muscle. Energy stress, used deliberately, becomes the tool for managing body fatness without sacrificing the performance and muscle you’ve worked for.

Related Episodes & Links:

• Episode 178 | Athletic Longevity isn’t Easy | Brendan Egan PhD/
• Episode 154 Adaptive Range Expansion for Peak Performance | Mike T Nelson PhD
• Episode 144 | Muscle for Athletic Performance | Mark Tarnopolsky MD PhD
• Episode 71 | Framework for Durability | Dr Nick Dinubile
• Episode 65 | Optimizing Aging Muscle | Brendan Egan PhD

Help the show:

3 ways to support our show: 

• Leave a review (or share this episode)
• Check out our Fullscript site to save big on high quality supplements. Thank you!
• Email us your questions at info@wiseathletes.com.